ABNORMAL REPRESSION OF SHP-1, SHP-2 AND SOCS-1 TRANSCRIPTION SUSTAINS THE ACTIVATION OF THE JAK/STAT3 PATHWAY AND THE PROGRESSION OF THE DISEASE IN MULTIPLE MYELOMA.

Sustained activation of JAK/STAT3 signaling pathway is classically described in Multiple Myeloma (MM).One explanation could be the silencing of the JAK/STAT suppressor genes, through the hypermethylation of SHP-1 and SOCS-1, previously demonstrated in MM cell lines or Entertainment Centers in whole bone marrow aspirates.The link between such suppre

The present study was intended to improve the chemical properties of a saline-sodic soil using the individual application of alfalfa residue and two biochars produced from sugarcane bagasse and walnut shell, at the weighting ratio of 5%; their concomitant application with gypsum, aluminum sulfate and the mixture of these two chemical amendments was

Carbon capture and storage is one of the potential options for reducing CO2 emissions from coal-fired power plants while preserving their operation.Mathematical modeling was carried out for a one-stage membrane process of carbon dioxide capture from the flue gases of coal-fired power plants using commercial gas separation membranes.Our calculations

Background: Most COVID-19 patients have mild or moderate illnesses that can progress to severe illness, leading to hospitalization and/or mortality.The use of antivirals to prevent the progression of COVID-19 in non-hospitalized patients shows conflicting result and efficacy remain unclear.This study evaluates the efficacy and safety of antivirals

Summary:.Advances in surgical instruments, magnification technology, perforator dissection techniques, and vascular imaging Coffee over the past decades have facilitated exponential growth in the field of microsurgery.With wide application potential including but not limited to limb salvage, breast reconstruction, lymphedema treatment, and sex affi